Ennio Esposito Selected Research

Dystonia (Limb Dystonia)

11/2007

Lu 35-138 ((+)-(S)-3-{1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-3,6-dihydro-2H-pyridin-4-yl}-6-chloro-1H-indole), a dopamine D4 receptor antagonist and serotonin reuptake inhibitor: characterisation of its in vitro profile and pre-clinical antipsychotic potential.

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Ennio Esposito Research Topics

Disease

12	Parkinson Disease (Parkinson's Disease) 01/2013 - 04/2002
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2009 - 09/2002
3	Schizophrenia (Dementia Praecox) 01/2008 - 04/2002
3	Substance-Related Disorders (Drug Abuse) 01/2008 - 04/2002
2	Motor Disorders 01/2008 - 01/2006
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 09/2007 - 04/2003
2	Necrosis 04/2003 - 09/2002
1	Hypoxia (Hypoxemia) 02/2010
1	Hyperoxia 02/2010
1	Brain Ischemia (Cerebral Ischemia) 02/2010
1	Tourette Syndrome (Tourette's Syndrome) 01/2008
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2008
1	Movement Disorders (Movement Disorder) 01/2008
1	Dystonia (Limb Dystonia) 11/2007
1	Catalepsy 11/2007
1	Tobacco Use Disorder (Nicotine Dependence) 01/2007
1	Nervous System Diseases (Neurological Disorders) 01/2006
1	Alzheimer Disease (Alzheimer's Disease) 04/2003

Drug/Important Bio-Agent (IBA)

4	Dopamine (Intropin)FDA LinkGeneric 02/2009 - 01/2008
3	AntioxidantsIBA 09/2007 - 09/2002
2	Oxidopamine (6 Hydroxydopamine)IBA 02/2009 - 02/2009
2	Serotonin (5 Hydroxytryptamine)IBA 01/2008 - 01/2008
2	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2003 - 09/2002
2	PolyphenolsIBA 04/2003 - 09/2002
2	Transcription Factors (Transcription Factor)IBA 04/2003 - 09/2002
2	NF-kappa B (NF-kB)IBA 04/2003 - 09/2002
2	Vitamin E FDA LinkGeneric 04/2003 - 09/2002
1	Proteasome InhibitorsIBA 01/2013
1	Protons (Proton)IBA 02/2010
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 02/2009
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2008
1	3- (1- (2- (1- acetyl- 2,3- dihydro- 1H- indol- 3- yl)ethyl)- 3,6- dihydro- 2H- pyridin- 4- yl)- 6- chloro- 1H- indoleIBA 11/2007
1	Pyruvic Acid (Pyruvate)IBA 09/2007
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 06/2007
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 06/2007
1	5-HT2C Serotonin ReceptorIBA 01/2006
1	Therapeutic UsesIBA 04/2003

Therapy/Procedure

2	Therapeutics 06/2007 - 04/2002
1	Ligation 02/2010
1	Drug Therapy (Chemotherapy) 01/2007